CentralNotice From Wikipedia, the free encyclopedia Jump to: navigation , search Intraosseous infusion Two pictures of the EZ IO device. eMedicine 80431 [ edit on Wikidata ] The tibia IO insertion site is just below the medial condyle, labeled in this picture. Intraosseous infusion ( IO ) is the process of injecting directly into the marrow of a bone. This provides a non-collapsible entry point into the systemic venous system . [1] This technique is used to provide fluids and medication when intravenous access is not available or not feasible. Intraosseous infusions allow for the administered medications and fluids to go directly into the vascular system. [2] A comparison of intravenous (IV), intramuscular (IM), and intraosseous (IO) routes of administration concluded that the intraosseous route is demonstrably superior to intramuscular and compar...