CentralNotice From Wikipedia, the free encyclopedia Jump to: navigation , search A secretagogue is a substance that causes another substance to be secreted . One example is gastrin , [ 1 ] which stimulates the H/K ATPase in the parietal cells (increased gastric acid production by the stomach ). Pentagastrin , a synthetic gastrin, histamine , and acetylcholine are also gastric secretagogues. Sulfonylureas are insulin secretagogues, triggering insulin release by direct action on the K ATP channel of the pancreatic beta cells . Blockage of this channel leads to depolarization and secretion of vesicles. Angiotensin II is a secretagogue for aldosterone from the adrenal gland . References [ edit ] ^ secretagogue at eMedicine Dictionary [ dead link ] External links [ edit ] " Secretagogue " at Dorland's Medical Dictionary This human digestive system article is a st...